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Inhibition of Src with AZD0530 Reveals the Src-Focal Adhesion Kinase Complex as a Novel Therapeutic Target in Papillary and Anaplastic Thyroid Cancer

机译：AZD0530对Src的抑制作用揭示了Src-粘着斑激酶复合物是乳头状和间变性甲状腺癌的新型治疗靶标。

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Context: Focal adhesion kinase (FAK) and Src are overexpressed and activated in many cancers and have been associated with tumor progression. The role of the Src-FAK complex has not been characterized in papillary and anaplastic thyroid cancer (PTC and ATC).

机译：背景：黏着斑激酶（FAK）和Src在许多癌症中均过表达和激活，并与肿瘤进展相关。在乳头状和间变性甲状腺癌（PTC和ATC）中，尚未鉴定出Src-FAK复合物的作用。

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Schweppe, Rebecca E.; Kerege, Anna A.; French, Jena D.; Sharma, Vibha; Grzywa, Rachel L.; Haugen, Bryan R.;
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年度 2009
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1. Insulin-Like Growth Factor-1 Receptor Signaling Increases the Invasive Potential of Human Epidermal Growth Factor Receptor 2-Overexpressing Breast Cancer Cells via Src-Focal Adhesion Kinase and Forkhead Box Protein M1 [J] . Sanabria-Figueroa Eduardo, Donnelly Siobhan M., Foy Kevin C., Molecular pharmacology. . 2015,第2期

机译：胰岛素样生长因子-1受体信号通过Src-Focal粘附激酶和叉头盒蛋白M1增加人表皮生长因子受体2过表达的乳腺癌细胞的侵袭潜力。
2. Evaluation of Aurora kinase inhibition as a new therapeutic strategy in anaplastic and poorly differentiated follicular thyroid cancer. [J] . Wunderlich A, Fischer M, Schlosshauer T, Cancer science. . 2011,第4期

机译：评价Aurora激酶抑制作为间变性和低分化滤泡性甲状腺癌的新治疗策略。
3. Evaluation of Aurora kinase inhibition as a new therapeutic strategy in anaplastic and poorly differentiated follicular thyroid cancer [J] . Annette Ramaswamy, Annette Wunderlich, Brandon H. Greene, Cancer science. . 2011,第4期

机译：评价Aurora激酶抑制作为间变性和低分化滤泡性甲状腺癌的新治疗策略
4. Selective tyrosine kinase inhibitor, STI571, inhibitsgrowth of p53 mutant anaplastic thyroid cancer cellsby inducing S-G2 transition arrest [C] . Alexei P. Podtcheko, Satoshi Tsuda, Akira Ohtsuru International Consortium for Medical Care of Hibakusha and Radiation Life Science . 2003

机译：选择性酪氨酸激酶抑制剂，STI571，P53突变体的抑制性诱导S-G2过渡逮捕的抑制性甲状腺癌细胞
5. HIV-1 Nef-Src family kinase interaction: A novel target for the inhibition of HIV-1 pathogenesis [D] . Narute, Purushottam S. 2012

机译：HIV-1 Nef-Src家族激酶相互作用：抑制HIV-1发病机制的新目标。
6. Inhibition of Src with AZD0530 Reveals the Src-Focal Adhesion Kinase Complex as a Novel Therapeutic Target in Papillary and Anaplastic Thyroid Cancers [O] . Rebecca E. Schweppe, Anna A. Kerege, Jena D. French, -1

机译：AZD0530对Src的抑制作用揭示了Src-粘着斑激酶复合物是乳头状和间变性甲状腺癌的新型治疗靶标。
7. Inhibition of Src with AZD0530 Reveals the Src-Focal Adhesion Kinase Complex as a Novel Therapeutic Target in Papillary and Anaplastic Thyroid Cancers [O] . Rebecca E. Schweppe, Anna A. Kerege, Jena D. French, 2009

机译：用AZD0530的SRC抑制揭示了SRC-ocalaL粘附激酶复合物作为乳头状和骨盆甲状腺癌中的新型治疗靶标

Inhibition of Src with AZD0530 Reveals the Src-Focal Adhesion Kinase Complex as a Novel Therapeutic Target in Papillary and Anaplastic Thyroid Cancer

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